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  • GLP-1 News for Thursday, November 14, 2024

GLP-1 News for Thursday, November 14, 2024

This Protein Could Affect Weight Loss From Exercise, Ozempic | Ozempic Could Prevent Diabetes. Should We Use It For That? | Ozempic, Wegovy Could Help Alcoholics Cut Back, New Study Suggests | Weight loss meds help stroke survivors prevent stroke recurrence, death

What we’re hearing

Last week’s developments in GLP-1 drugs highlight transformative advancements across weight management, addiction treatment, fertility, and broader health outcomes. Scientific breakthroughs are paving new paths, with discoveries in proteins like PGC-1α and KLF-15 offering potential for future GLP-1-inspired medications that could target weight loss and metabolic health more directly. Additionally, research suggests that GLP-1 drugs, particularly Ozempic and Wegovy, may play a role in reducing problem drinking and supporting preconception care, which is sparking interest among fertility specialists.

Studies presented at the American Heart Association underscored the cardioprotective benefits of GLP-1 receptor agonists (RAs) and SGLT-2 inhibitors in stroke and heart attack prevention, especially for stroke survivors, highlighting a substantial opportunity for GLP-1 drugs beyond diabetes and obesity. Novo Nordisk’s successful Phase III trial results for semaglutide’s efficacy in metabolic dysfunction-associated steatohepatitis (MASH) suggest an expanded application scope, further strengthened by emerging evidence of GLP-1’s kidney-protective and Alzheimer’s prevention potential. On the commercial front, Novo Nordisk’s announcement of CagriSema—a semaglutide-based treatment promising significant weight loss—intensifies competition within the GLP-1 market.

Accessibility challenges and legal issues continue to shape the landscape. High costs and insurance limitations persist as significant barriers, as Medicaid spending on GLP-1 drugs has surged over 500% since 2019. This rapid increase underscores the broader issue of accessibility for those without comprehensive insurance, as high-profile cases of health complications linked to compounded GLP-1 drugs, like off-label semaglutide, lead to increased regulatory scrutiny. Furthermore, Novo Nordisk’s mixed sales results reveal both the immense demand and operational bottlenecks in this expanding market, with consumer demand heavily outpacing supply.

The week closed with new FDA warnings regarding the potential for pulmonary aspiration with GLP-1 drugs under anesthesia, adding a layer of caution for both providers and patients. While GLP-1 medications are reshaping treatment options, these ongoing studies and regulatory developments signal the need for balanced and informed use as these drugs gain traction across therapeutic areas.

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